Recombinant Human DDHD1 Protein, MYC/DDK-tagged

• Cat.No.: DDHD1-229H
• Product Overview: Recombinant Human DDHD1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 96.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DDHD1 DDHD domain containing 1 [ Homo sapiens ]
• Official Symbol: DDHD1
• Synonyms: SPG28; PAPLA1; PA-PLA1
• Gene ID: 80821
• mRNA Refseq: NM_030637
• Protein Refseq: NP_085140
• MIM: 614603