Recombinant Human DGAT1 protein, His/SUMO-tagged

• Cat.No.: DGAT1-26H
• Product Overview: Recombinant Human DGAT1(1-488 aa) fused with His/SUMO tag was expressed in E.coli.

Specification

• Description: This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.
• Source: E. coli
• Species: Human
• Tag: His/SUMO
• Form: Tris-based buffer,50% glycerol
• Protein length: 1-488 aa
• AA Sequence: MGDRGSSRRRRTGSRPSSHGGGGPA AAEEEVRDAAAGPDVGAAGDAPAPA PNKDGDAGVG SGHWELRCHRLQDSLFSSDSGFSNY RGILNWCVVMLILSNARLFLENLIK YGILVDPIQV VSLFLKDPYSWPAPCLVIAANVFAV AAFQVEKRLAVGALTEQAGLLLHVA NLATILCFPA AVVLLVESITPVGSLLALMAHTILF LKLFSYRDVNSWCRRARAKAASAGK KASSAAAPHT VSYPDNLTYRDLYYFLFAPTLCYEL NFPRSPRIRKRFLLRRILEMLFFTQ LQVGLIQQWM VPTIQNSMKPFKDMDYSRIIERLLK LAVPNHLIWLIFFYWLFHSCLNAVA ELMQFGDREF YRDWWNSESVTYFWQNWNIPVHKWC IRHFYKPMLRRGSSKWMARTGVFLA SAFFHEYLVS VPLRMFRLWAFTGMMAQIPLAWFVG RFFQGNYGNAAVWLSLIIGQPIAVL MYVHDYYVLN YEAPAAEA
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade.

Gene Information

• Gene Name: DGAT1 diacylglycerol O-acyltransferase 1 [ Homo sapiens ]
• Official Symbol: DGAT1
• Synonyms: DGAT1; diacylglycerol O-acyltransferase 1; diacylglycerol O acyltransferase homolog 1 (mouse); ARGP1; DGAT; ACAT related gene product 1; ACAT-related gene product 1; diglyceride acyltransferase; diacylglycerol O-acyltransferase homolog 1; acyl coenzyme A:cholesterol acyltransferase related gene 1
• Gene ID: 8694
• mRNA Refseq: NM_012079
• Protein Refseq: NP_036211
• MIM: 604900
• UniProt ID: O75907
• Chromosome Location: 8q24.3
• Pathway: Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: 2-acylglycerol O-acyltransferase activity; O-acyltransferase activity; diacylglycerol O-acyltransferase activity; diacylglycerol binding; fatty acid binding; transferase activity, transferring acyl groups