Recombinant Human DHX9 protein, His/SUMO-tagged

• Cat.No.: DHX9-32H
• Product Overview: Recombinant Human DHX9(aa 325-840) fused with His/SUMO tag was expressed in E. coli.

Specification

• Description: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
• Source: E. coli
• Species: Human
• Tag: His/SUMO
• Form: 20 mM Tris, pH 8.0, 500 mM NaCl, 50% glycerol
• Molecular Mass: 74.5 kD
• AA Sequence: NQVGVVPWSP PQSNWNPWTS SNIDEGPLAF ATPEQISMDLKNELMYQLEQ DHDLQAILQE RELLPVKKFE SEILEAISQNSVVIIRGATG CGKTTQVPQF ILDDFIQNDR AAECNIVVTQ
  PRRISAVSVA ERVAFERGEE PGKSCGYSVR FESILPRPHASIMFCTVGVL LRKLEAGIRG ISHVIVDEIH ERDINTDFLLVVLRDVVQAY PEVRIVLMSA TIDTSMFCEY FFNCPIIEVY
  GRTYPVQEYF LEDCIQMTHF VPPPKDKKKK DKDDDGGEDDDANCNLICGD EYGPETRLSM SQLNEKETPF ELIEALLKYIETLNVPGAVL VFLPGWNLIY TMQKHLEMNP HFGSHRYQIL
  PLHSQIPREE QRKVFDPVPV GVTKVILSTN IAETSITINDVVYVIDSCKQ KVKLFTAHNN MTNYATVWAS KTNLEQRKGRAGRVRPGFCF HLCSRARFER LETHMTPEMF RTPLHEIALS
  IKLLRLGGIG QFLAKAIEPP PLDAVIEAEH TLRELD
• Storage: Long term: -80 centigrade; Short term: -20 centigrade. Avoid freeze-thaw cycles.

Gene Information

• Gene Name: DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 [ Homo sapiens ]
• Official Symbol: DHX9
• Synonyms: DHX9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DDX9, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA helicase II; leukophysin) , LKP; ATP-dependent RNA helicase A; NDH II; RHA; leukophysin; DEAH box protein 9; nuclear DNA helicase II; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9; LKP; DDX9; NDH2; NDHII; FLJ17406
• Gene ID: 1660
• mRNA Refseq: NM_001357
• Protein Refseq: NP_001348
• MIM: 603115
• UniProt ID: Q08211
• Chromosome Location: 1q25
• Pathway: Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; mRNA Splicing, organism-specific biosystem; mRNA Splicing - Major Pathway, organism-specific biosystem; mRNA processing, organism-specific biosystem
• Function: ATP binding; ATP-dependent DNA helicase activity; ATP-dependent RNA helicase activity; DNA binding; RNA helicase activity; RNA polymerase II transcription factor binding; double-stranded RNA binding; hydrolase activity; nucleotide binding; protein binding