| Description : |
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
65.7 kDa |
| AA Sequence : |
MLLLPSAADGRGTAITHALTSASTL CQVEPVGRWFEAFVKRRNRNASASF QELEDKKELSEESEDEELQLEEFPM LKTLDPKDWKNQDHYAVLGLGHVRY KATQRQIKAAHKAMVLKHHPDKRKA AGEPIKEGDNDYFTCITKAYEMLSD PVKRRAFNSVDPTFDNSVPSKSEAK DNFFEVFTPVFERNSRWSNKKNVPK LGDMNSSFEDVDIFYSFWYNFDSWR EFSYLDEEEKEKAECRDERRWIEKQ NRATRAQRKKEEMNRIRTLVDNAYS CDPRIKKFKEEEKAKKEAEKKAKAE AKRKEQEAKEKQRQAELEAARLAKE KEEEEVRQQALLAKKEKDIQKKAIK KERQKLRNSCKIEEINEQIRKEKEE AEARMRQASKNTEKSTGGGGNGSKN WSEDDLQLLIKAVNLFPAGTNSRWE VIANYMNIHSSSGVKRTAKDVIGKA KSLQKLDPHQKDDINKKAFDKFKKE HGVVPQADNATPSERFEGPYTDFTP WTTEEQKLLEQALKTYPVNTPERWE KIAEAVPGRTKKDCMKRYKELVEMV KAKKAAQEQVLNASRAKKTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
