| Description : |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
32.8 kDa |
| AA Sequence : |
MGRKVHSNGSQFAEHSRSPRRTGRD CKPVRAPSMALGVSQLAGRSRCLCS ESQGGYERFSSEYPEFCSKTKALAA IPPPVPPSATEPLDLGCSSCGTPLH DQGGPVEILPFLYLGSAYHAARRDM LDALGITALLNVSSDCPNHFEGHYQ YKCIPVEDNHKADISSWFMEAIEYI DAVKDCRGRVLVHCQAGISRSATIC LAYLMMKKRVRLEEAFEFVKQRRSI ISPNFSFMGQLLQFESQVLATSCAA EAASPSGPLRERGKTPATPTSQFVF SFPVSVGVHSAPSSLPYLHSPITTS PSCTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
