| Description : |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
41.9 kDa |
| AA Sequence : |
MEGLGRSCLWLRRELSPPRPRLLLL DCRSRELYESARIGGALSVALPALL LRRLRRGSLSVRALLPGPPLQPPPP APVLLYDQGGGRRRRGEAEAEAEEW EAESVLGTLLQKLREEGYLAYYLQG GFSRFQAECPHLCETSLAGRAGSSM APLPGPVPVVGLGSLCLGSDCSDAE SEADRDSMSCGLDSEGATPPPVGLR ASFPVQILPNLYLGSARDSANLESL AKLGIRYILNVTPNLPNFFEKNGDF HYKQIPISDHWSQNLSRFFPEAIEF IDEALSQNRGVLVHCLAGVSRSVTV TVAYLMQKLHLSLNDAYDLVKRKKS NISPNFNFMGQLLDFERSLRLEERH SQEQGSGGQASAASNPPSFFTTPTS DGAFELAPTTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
