"EDN1" Related Products


Recombinant Human EDN1 protein, His-tagged

Cat.No.: EDN1-32H
Product Overview: Recombinant Human EDN1 fused with His tag at N-terminal was expressed in E. coli.
Description: Endothelin 1, also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin (ET-1).Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.
Source: E. coli
Species: Human
Tag: His
Form: Lyophilized from 50mM Tris-HCL,0.5mM EDTA,50mM NaCl, pH 7.4
Molecular Mass: 13 kDa
Purity: > 90% as determined by SDS-PAGE
Applications: Western blotting, ELISA
Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.
Reconstitution: Reconstitute in ddH2O
Gene Name: EDN1 endothelin 1 [ Homo sapiens ]
Official Symbol: EDN1
Synonyms: EDN1; endothelin 1; endothelin-1; ET1; preproendothelin-1; PPET1; HDLCQ7;
Gene ID: 1906
mRNA Refseq: NM_001168319
Protein Refseq: NP_001161791
UniProt ID: P05305
Chromosome Location: 6p24.1
Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; EGFR-dependent Endothelin signaling events, organism-specific biosystem; Endothelins, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem;
Function: cytokine activity; endothelin A receptor binding; endothelin B receptor binding; endothelin B receptor binding; hormone activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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