Recombinant Human EGF Protein

Cat.No.: EGF-3112H
Product Overview: Human EGF (P01133, 1 a.a. - 247 a.a.) full-length recombinant protein expressed in Escherichia coli.
Description: This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Source: E. coli
Species: Human
Form: Lyophilized
Bio-activity: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.5 ng/mL, corresponding to a specific activity of ≥2 x 107 units/mg.
Molecular Mass: 6 kDa
AA Sequence: REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ
Endotoxin: < 0.1 ng/μg (1 EU/μg)
Purity: > 90% by SDS-PAGE and HPLC
Applications: Functional Study
SDS-PAGE
Storage: Store at -20 centigrade on dry atmosphere for 2 years.After reconstitution with deionized water, store at 4 centigrade for 1 month or store at -20 centigrade for 6 months.Aliquot to avoid repeated freezing and thawing.
Storage Buffer: Lyophilized from PBS, pH 7.2
Gene Name: EGF epidermal growth factor [ Homo sapiens ]
Official Symbol: EGF
Synonyms: EGF; epidermal growth factor; epidermal growth factor (beta urogastrone); pro-epidermal growth factor; beta-urogastrone; URG; HOMG4;
Gene ID: 1950
mRNA Refseq: NM_001178130
Protein Refseq: NP_001171601
MIM: 131530
UniProt ID: P01133

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