Recombinant Human EIF6 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: EIF6-671H
• Product Overview: EIF6 MS Standard C13 and N15-labeled recombinant protein (NP_852133) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 26.4 kDa
• AA Sequence: MAVRASFENNCEIGCFAKLTNTYCL VAIGGSENFYSVFEGELSDTIPVVH ASIAGCRIIGRMCVGNRHGLLVPNN TTDQELQHIRNSLPDTVQIRRVEER LSALGNVTTCNDYVALVHPDLDRET EEILADVLKVEVFRQTVADQVLVGS YCVFSNQGGLVHPKTSIEDQDELSS LLQVPLVAGTVNRGSEVIAAGMVVN DWCAFCGLDTTSTELSVVESVFKLN EAQPSTIATSMRDSLIDSLTTRRLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: EIF6 eukaryotic translation initiation factor 6 [ Homo sapiens (human) ]
• Official Symbol: EIF6
• Synonyms: EIF6; eukaryotic translation initiation factor 6; EIF3A, integrin beta 4 binding protein, ITGB4BP; b(2)gcn; p27BBP; B4 integrin interactor; p27 beta-4 integrin-binding protein; eukaryotic translation initiation factor 3A; CAB; EIF3A; eIF-6; ITGB4BP; p27(BBP)
• Gene ID: 3692
• mRNA Refseq: NM_181468
• Protein Refseq: NP_852133
• MIM: 602912
• UniProt ID: P56537