Recombinant Human EPCAM Protein, Strep-tagged
Cat.No. : | EPCAM-223H |
Product Overview : | Recombinant human EPCAM protein with Strep tag was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. |
Source : | HEK293 |
Species : | Human |
Tag : | Strep |
Form : | Lyophilized |
Molecular Mass : | 30.4 kDa |
Protein Length : | 314 |
AA Sequence : | MAPPQVLAFGLLLAAATATFAAAQE ECVCENYKLAVNCFVNNNRQCQCTS VGAQNTVICSKLAAKCLVMKAEMNG SKLGRRAKPEGALQNNDGLYDPDCD ESGLFKAKQCNGTSMCWCVNTAGVR RTDKDTEITCSERVRTYWIIIELKH KAREKPYDSKSLRTALQKEITTRYQ LDPKFITSILYENNVITIDLVQNSS QKTQNDVDIADVAYYFEKDVKGESL FHSKKMDLTVNGEQLDLDPGQTLIY YVDEKAPEFSMQGLKAGVIAVIVVV VIAVVAGIVVLVISRKKRMAKYEKA EIKEMGEMHRELNA |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | EPCAM epithelial cell adhesion molecule [ Homo sapiens (human) ] |
Official Symbol : | EPCAM |
Synonyms : | EPCAM; epithelial cell adhesion molecule; antigen identified by monoclonal AUA1 , M4S1, MIC18, TACSTD1, tumor associated calcium signal transducer 1; 17 1A; 323/A3; CD326; CO 17A; EGP 2; EGP34; EGP40; Ep CAM; ESA; GA733 2; HEA125; KS1/4; KSA; Ly74; MH99; MK 1; MOC31; TACST 1; TROP1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); M4S1; MK-1; DIAR5; EGP-2; MIC18; EGP314; HNPCC8; TACSTD1; GA733-2; |
Gene ID : | 4072 |
mRNA Refseq : | NM_002354 |
Protein Refseq : | NP_002345 |
MIM : | 185535 |
UniProt ID : | P16422 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (7)
Ask a questionEpCAM is highly expressed in epithelial tissues and some cancer cells.
It has a controversial role in cell adhesion, possibly contributing to both cell-cell adhesion and anti-adhesive properties.
EpCAM primarily functions in cell signaling, proliferation, and migration.
It often has a pro-tumorigenic role, promoting cancer cell proliferation, migration, and invasion.
EpCAM is used as a biomarker to detect and isolate circulating tumor cells.
Strategies include developing EpCAM-targeted therapies for cancer treatment.
Genetic alterations in EpCAM are linked to some hereditary cancer syndromes.
Customer Reviews (3)
Write a reviewReliable for assays, satisfied customer.
High-quality product, consistent results.
Quick delivery, product as described.
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