| Cat.No. : |
ERBB4-2052H |
| Product Overview : |
Recombinant Human Rhesus HER4/ErbB4 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln26-Arg649) of human Rhesus HER4/ErbB4 (Accession #NP_005226.1) fused with an Fc, 6×His tag at the C-terminus. |
| Description : |
Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc/His |
| Form : |
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol. |
| Protein length : |
Gln26-Arg649 |
| Endotoxin : |
< 1.0 EU per μg of the protein as determined by the LAL method. |
| Purity : |
> 90% as determined by SDS-PAGE |
| Stability : |
Samples are stable for up to twelve months from date of receipt at -70ºC. |
| Storage : |
Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution : |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.