Cat.No. : |
ERBB4-2052H |
Product Overview : |
Recombinant Human Rhesus HER4/ErbB4 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln26-Arg649) of human Rhesus HER4/ErbB4 (Accession #NP_005226.1) fused with an Fc, 6×His tag at the C-terminus. |
Description : |
Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Fc/His |
Form : |
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol. |
Protein length : |
Gln26-Arg649 |
Endotoxin : |
< 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : |
> 90% as determined by SDS-PAGE |
Stability : |
Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : |
Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |