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| Cat.No.: | ERBB4-2052H |
| Product Overview: | Recombinant Human Rhesus HER4/ErbB4 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln26-Arg649) of human Rhesus HER4/ErbB4 (Accession #NP_005226.1) fused with an Fc, 6×His tag at the C-terminus. |
| Description: | Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor subfamily. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. |
| Source: | HEK293 |
| Species: | Human |
| Tag : | Fc/His |
| Form: | Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol. |
| Protein length: | Gln26-Arg649 |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Purity: | > 90% as determined by SDS-PAGE |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70ºC. |
| Storage: | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| Gene Name: | ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) [ Homo sapiens ] |
| Official Symbol: | ERBB4 |
| Synonyms: | ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); v erb a avian erythroblastic leukemia viral oncogene homolog like 4; receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; HER4; p180erbB4; MGC138404; |
| Gene ID: | 2066 |
| mRNA Refseq: | NM_001042599 |
| Protein Refseq: | NP_001036064 |
| MIM: | 600543 |
| UniProt ID: | Q15303 |
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