Active Recombinant Human EWSR1 Protein, Myc/DDK-tagged

• Cat.No.: EWSR1-05H
• Product Overview: Recombinant protein of human Ewing sarcoma breakpoint region 1 (EWSR1), transcript variant EWS with C-terminal Myc/DDK tag, expressed in HEK293T.

Specification

• Description: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
• Source: HEK293T
• Species: Human
• Tag: Myc/DDK
• Bio-activity: Transmission electron microscopy; In vitro kinase assay inhibitor
• Molecular Mass: 68.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: EWSR1 EWS RNA binding protein 1 [ Homo sapiens (human) ]
• Official Symbol: EWSR1
• Synonyms: EWSR1; EWS RNA binding protein 1; EWS; EWS-FLI1; bK984G1.4; RNA-binding protein EWS; EWS RNA-binding protein variant 6; Ewing sarcoma breakpoint region 1; Ewings sarcoma EWS-Fli1 (type 1) oncogene
• Gene ID: 2130
• mRNA Refseq: NM_005243
• Protein Refseq: NP_005234
• MIM: 133450
• UniProt ID: Q01844