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Recombinant Human EZH2 Complex protein, His/Flag-tagged

Cat.No. : EZH2-164H
Product Overview : Mutant version of EZH2 5-member complex, but with a Glu-to-Lys mutation on a.a. 745 of the EZH2 protein.* Complex of human EZH2 (GenBank Accession No. NM_004456), (a.a. 2-end; E745K) with N-terminal His-tag, MW= 86 kDa, human EED (NM_003797) (a.a. 2-end) with N-terminal FLAG-tag, MW= 51 kDa, human SUZ12 (NM_015355) (a.a. 2-end) with N-terminal His-tag, MW = 87 kDa, Human AEBP2 (NM_153207) (a.a. 2-end) with N-terminal His-tag, MW= 53 kDa, and human RbAp48 (NM_005610) (a.a. 2-end) with N-terminal His-tag, MW = 48 kDa, co-expressed in a baculovirus expression system.
  • Specification
  • Gene Information
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Source : Insect cells
Species : Human
Tag : His/Flag
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol
Molecular Mass : 325 kDa (complex)
Protein length : 2–end (all components)
AA Sequence : MHHHHHHGQTGKKSEKGPVCWRKRV KSEYMRLRQLKRFRRADEVKSMFSS NRQKILERTEILNQEWKQRRIQPVH ILTSVSSLRGTRECSVTSDLDFPTQ VIPLKTLNAVASVPIMYSWSPLQQN FMVEDETVLHNIPYMGDEVLDQDG TFIEELIKNYDGKVHGDRECGFIND EIFVELVNALGQYNDDDDDDDGDDP EEREEKQKDLEDHRDDKESRPPRKF PSDKIFEAISSMFPDKGTAEELKEK YKELTEQQLPGALPPECTPNIDGPN AKSVQREQSLHSFHTLFCRRCFKY DCFLHRKCNYSFHATPNTYKRKNTE TALDNKPCGPQCYQHLEGAKEFAAA LTAERIKTPPKRPGGRRRGRLPNN SSRPSTPTINVLESKDTDSDREAGT ETGGENNDKEEEEKKDETSSSSEAN SRCQTPIKMKPNIEPPENVEWSGAE ASMFRVLIGTYYDNFCAIARLIGTK TCRQVYEFRVKESSIIAPAPAEDVD TPPRKKKRKHRLWAAHCRKIQLKK DGSSNHVYNYQPCDHPRQPCDSSCP CVIAQNFCEKFCQCSSECQNRFPGC RCKAQCNTKQCPCYLAVRECDPDL CLTCGAADHWDSKNVSCKNCSIQRG SKKHLLLAPSDVAGWGIFIKDPVQK NEFISEYCGEIISQDEADRRGKVYD KYMCSFLFNLNNDFVVDATRKGNKI RFANHSVNPNCYAKVMMVNGDHRIG IFAKRAIQTGEELFFDYRYSQADA LKYVGIKREMEIP
Purity : ≥ 81%
Applications : Useful for Western blot analysis and to investigate protein-protein interactions in the EZH2 complex.
Storage : >6 months at -70 centigrade. Avoid freeze/thaw cycles
Concentration : 0.38 mg/ml
Gene Name : EZH2 enhancer of zeste homolog 2 (Drosophila) [ Homo sapiens ]
Official Symbol : EZH2
Synonyms : EZH2; enhancer of zeste homolog 2 (Drosophila); enhancer of zeste (Drosophila) homolog 2; histone-lysine N-methyltransferase EZH2; ENX 1; EZH1; KMT6; KMT6A; lysine N-methyltransferase 6; ENX1; WVS2; ENX-1; MGC9169;
Gene ID : 2146
mRNA Refseq : NM_004456
Protein Refseq : NP_004447
MIM : 601573
UniProt ID : Q15910
Chromosome Location : 7q35-q36
Function : DNA binding; histone methyltransferase activity; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is EZH2 overexpression associated with cancer progression? 11/20/2019

EZH2 overexpression is associated with promoting tumor cell proliferation, invasion, and metastasis, leading to cancer progression.

Are there any non-oncological clinical applications of EZH2? 07/29/2019

EZH2 has been implicated in various non-oncological conditions, including cardiovascular diseases and neurodegenerative disorders.

What are the potential side effects of EZH2 inhibitors in clinical use? 03/15/2017

Potential side effects may include hematological toxicity, gastrointestinal issues, and liver enzyme elevation.

How can EZH2 be targeted for cancer therapy? 08/17/2016

Small molecule inhibitors of EZH2 have been developed and are being investigated as potential cancer therapies.

Are there any prognostic implications of EZH2 expression in cancer patients? 08/15/2016

High EZH2 expression has been associated with poor prognosis in several cancer types.

Customer Reviews (3)

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Reviews
10/17/2022

    The versatility of the EZH2 protein is truly remarkable, as it can be employed across a wide range of applications in my research.

    03/14/2018

      In addition to its outstanding quality, the manufacturer of the EZH2 protein offers excellent technical support that can effectively address any challenges I may encounter.

      02/27/2018

        Their dedicated team of experts is readily available to provide guidance and assistance, ensuring a seamless integration of the EZH2 protein into my experimental setup.

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