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Recombinant Human F10 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : F10-769H
Product Overview : F10 MS Standard C13 and N15-labeled recombinant protein (NP_000495) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 54.7 kDa
AA Sequence : MGRPLHLVLLSASLAGLLLLGESLF IRREQANNILARVTRANSFLEEMKK GHLERECMEETCSYEEAREVFEDSD KTNEFWNKYKDGDQCETSPCQNQGK CKDGLGEYTCTCLEGFEGKNCELFT RKLCSLDNGDCDQFCHEEQNSVVCS CARGYTLADNGKACIPTGPYPCGKQ TLERRKRSVAQATSSSGEAPDSITW KPYDAADLDPTENPFDLLDFNQTQP ERGDNNLTRIVGGQECKDGECPWQA LLINEENEGFCGGTILSEFYILTAA HCLYQAKRFKVRVGDRNTEQEEGGE AVHEVEVVIKHNRFTKETYDFDIAV LRLKTPITFRMNVAPACLPERDWAE STLMTQKTGIVSGFGRTHEKGRQST RLKMLEVPYVDRNSCKLSSSFIITQ NMFCAGYDTKQEDACQGDSGGPHVT RFKDTYFVTGIVSWGEGCARKGKYG IYTKVTAFLKWIDRSMKTRGLPKAK SHAPEVITSSPLKTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : F10 coagulation factor X [ Homo sapiens (human) ]
Official Symbol : F10
Synonyms : F10; coagulation factor X; factor Xa; prothrombinase; Stuart-Prower factor; FX; FXA;
Gene ID : 2159
mRNA Refseq : NM_000504
Protein Refseq : NP_000495
MIM : 613872
UniProt ID : P00742

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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