Recombinant Human FGFR1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | FGFR1-1895H |
Product Overview : | FGFR1 MS Standard C13 and N15-labeled recombinant protein (NP_075596) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 30.6 kDa |
AA Sequence : | MWSWKCLLFWAVLVTATLCTARPSP TLPEQDALPSSEDDDDDDDSSSEEK ETDNTKPNPVAPYWTSPEKMEKKLH AVPAAKTVKFKCPSSGTPNPTLRWL KNGKEFKPDHRIGGYKVRYATWSII MDSVVPSDKGNYTCIVENEYGSINH TYQLDVVERSPHRPILQAGLPANKT VALGSNVEFMCKVYSDPQPHIQWLK HIEVNGSKIGPDNLPYVQILKVIMA PVFVGQSTGKETTVSGAQVPVGRLS CPRMGSFLTLQAHTLHLSRDLATSP RTSNRGHKVEVSWEQRAAGMGGAGL TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens (human) ] |
Official Symbol : | FGFR1 |
Synonyms : | FGFR1; fibroblast growth factor receptor 1; FLT2, fms related tyrosine kinase 2, KAL2; BFGFR; CD331; CEK; FLG; H2; H3; H4; H5; N SAM; Pfeiffer syndrome; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; OGD; FLT2; KAL2; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; bFGF-R-1; FLJ99988; |
Gene ID : | 2260 |
mRNA Refseq : | NM_023108 |
Protein Refseq : | NP_075596 |
MIM : | 136350 |
UniProt ID : | P11362 |
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◆ Lysates | ||
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◆ Assay kits | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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