| Description : |
The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
80.9 kDa |
| AA Sequence : |
MRLLLALLGVLLSVPGPPVLSLEAS EEVELEPCLAPSLEQQEQELTVALG QPVRLCCGRAERGGHWYKEGSRLAP AGRVRGWRGRLEIASFLPEDAGRYL CLARGSMIVLQNLTLITGDSLTSSN DDEDPKSHRDLSNRHSYPQQAPYWT HPQRMEKKLHAVPAGNTVKFRCPAA GNPTPTIRWLKDGQAFHGENRIGGI RLRHQHWSLVMESVVPSDRGTYTCL VENAVGSIRYNYLLDVLERSPHRPI LQAGLPANTTAVVGSDVELLCKVYS DAQPHIQWLKHIVINGSSFGADGFP YVQVLKTADINSSEVEVLYLRNVSA EDAGEYTCLAGNSIGLSYQSAWLTV LPGTGRIPHLTCDSLTPAGRTKSPT LQFSLESGSSGKSSSSLVRGVRLSS SGPALLAGLVSLDLPLDPLWEFPRD RLVLGKPLGEGCFGQVVRAEAFGMD PARPDQASTVAVKMLKDNASDKDLA DLVSEMEVMKLIGRHKNIINLLGVC TQEGPLYVIVECAAKGNLREFLRAR RPPGPDLSPDGPRSSEGPLSFPVLV SCAYQVARGMQYLESRKCIHRDLAA RNVLVTEDNVMKIADFGLARGVHHI DYYKKTSNGRLPVKWMAPEALFDRV YTHQSDVWSFGILLWEIFTLGGSPY PGIPVEELFSLLREGHRMDRPPHCP PELYGLMRECWHAAPSQRPTFKQLV EALDKVLLAVSEEYLDLRLTFGPYS PSGGDASSTCSSSDSVFSHDPLPLG SSSFPFGSGVQTTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
