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Recombinant Human FGFR4 Protein (22-369aa), C-His tagged

Cat.No. : FGFR4-5420H
Product Overview : Recombinant human FGFR4 (22-369aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
Source : Baculovirus
Species : Human
Tag : C-His
Form : Liquid
Molecular Mass : 39.5 kDa (356aa)
Protein Length : 22-369aa
AA Sequence : LEASEEVELEPCLAPSLEQQEQELT VALGQPVRLCCGRAERGGHWYKEGS RLAPAGRVRGWRGRLEIASFLPEDA GRYLCLARGSMIVLQNLTLITGDSL TSSNDDEDPKSHRDPSNRHSYPQQA PYWTHPQRMEKKLHAVPAGNTVKFR CPAAGNPTPTIRWLKDGQAFHGENR IGGIRLRHQHWSLVMESVVPSDRGT YTCLVENAVGSIRYNYLLDVLERSP HRPILQAGLPANTTAVVGSDVELLC KVYSDAQPHIQWLKHIVINGSSFGA DGFPYVQVLKTADINSSEVEVLYLR NVSAEDAGEYTCLAGNSIGLSYQSA WLTVLPEEDPTWTAAAPEARYTDLE HHHHHH
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 90% by SDS-PAGE
Applications : SDS-PAGE
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/mL (determined by absorbance at 280nm)
Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Name : FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens (human) ]
Official Symbol : FGFR4
Synonyms : FGFR4; fibroblast growth factor receptor 4; CD334; JTK2; FGFR-4; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; TKF; MGC20292;
Gene ID : 2264
mRNA Refseq : NM_002011
Protein Refseq : NP_002002
MIM : 134935
UniProt ID : P22455

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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