Recombinant Human GAD2 Protein, MYC/DDK-tagged
Cat.No. : | GAD2-22H |
Product Overview : | Recombinant protein of human glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (GAD2), transcript variant 1, was expressed in HEK293 cells. |
- Specification
- Gene Information
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Description : | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]. |
Source : | HEK293 cells |
Species : | Human |
Tag : | MYC/DDK |
Molecular Mass : | 65.2 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 µg/mL as determined by microplate BCA method. |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | GAD2 glutamate decarboxylase 2 [ Homo sapiens (human) ] |
Official Symbol : | GAD2 |
Synonyms : | GAD2; glutamate decarboxylase 2; GAD65; glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 65 kDa isoform; EC 4.1.1.15 |
Gene ID : | 2572 |
mRNA Refseq : | NM_000818 |
Protein Refseq : | NP_000809 |
MIM : | 138275 |
UniProt ID : | Q05329 |
Products Types
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◆ Lysates | ||
GAD2-001MCL | Recombinant Mouse GAD2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, genetic variations in the GAD2 gene have been associated with an increased risk of developing certain neurological disorders, indicating a genetic component in their etiology.
Pharmacological agents targeting GAD2 activity are being explored to modulate GABAergic neurotransmission, potentially offering novel treatments for neurological disorders.
Yes, elevated or reduced levels of GAD2 protein can serve as a diagnostic marker for certain neurological disorders, aiding in their identification and management.
GAD2 protein is linked to neurological disorders like epilepsy, Parkinson's disease, and various psychiatric conditions due to its role in regulating GABA levels, which are crucial for proper neuronal function.
Research is ongoing to develop therapeutic interventions that modulate GAD2 activity, aiming to restore GABAergic balance in the brain and potentially treat related neurological disorders.
Customer Reviews (3)
Write a reviewThe GAD2 protein exhibits remarkable performance in Western blotting (WB) experiments.
The versatility and efficacy of GAD2 in these applications make it an invaluable tool for researchers.
Researchers can rely on GAD2 to deliver reliable and accurate results in ELISA experiments, ensuring precise measurement and quantification of target proteins.
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