Active Recombinant Human GAS6 Protein(Leu136~Phe311), His-tagged
Cat.No. : | GAS6-546H |
Product Overview : | Recombinant Human GAS6 Protein(Leu136~Phe311), fused with N-terminal His tag, was expressed in E. coli. |
- Specification
- Gene Information
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Source : | E. coli |
Species : | Human |
Tag : | N-His |
Protein length : | Leu136~Phe311 |
Form : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 0.01% sarcosyl, 5% trehalose, and Proclin300. |
Bio-activity : | Growth arrest-specific 6, also known as GAS6, is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation. It has been reported that both PC-3 and DU 145 human prostate cancer cell lines are stimulated to proliferate by Gas6, however, this proliferative response strictly correlates with the expression of the Axl receptor, being higher in DU 145 cells. To test the proliferative effect of Gas6, DU 145 cells were seeded into triplicate wells of 96-well plates at a density of 2,000 cells/well and allowed to attach overnight, then the medium was replaced with serum-free standard DMEM prior to the addition of various concentrations of GAS6. After incubated for 72h, cells were observed by inverted microscope and cell proliferation was measure by Cell Counting Kit-8 (CCK-8). Briefly, 10μL of CCK-8 solution was added to each well of the plate, then measure the absorbance at 450nm using a microplate reader after incubating the plate for 1-4 hours at 37°C. |
Molecular Mass : | 24kDa |
Purity : | >92% |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | GAS6 growth arrest specific 6 [ Homo sapiens (human) ] |
Official Symbol : | GAS6 |
Synonyms : | GAS6; growth arrest specific 6; AXSF; AXLLG; growth arrest-specific protein 6; AXL receptor tyrosine kinase ligand; AXL stimulatory factor |
Gene ID : | 2621 |
mRNA Refseq : | NM_000820 |
Protein Refseq : | NP_000811 |
UniProt ID : | Q14393 |
Products Types
◆ Recombinant Protein | ||
GAS6-3014H | Recombinant Human GAS6 Protein, His (Fc)-Avi-tagged | +Inquiry |
GAS6-288TH | Recombinant Human GAS6 full-length, GST-tagged | +Inquiry |
Gas6-3478M | Recombinant Mouse Gas6 Protein, His (Fc)-Avi-tagged | +Inquiry |
GAS6-898M | Recombinant Mouse GAS6 Protein (Met1-Pro674), His-tagged | +Inquiry |
Gas6-1563R | Recombinant Rat Gas6 Protein, His&GST-tagged | +Inquiry |
◆ Lysates | ||
GAS6-6017HCL | Recombinant Human GAS6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionExpression level of GAS6 protein is associated with the occurrence and progression of cardiovascular disease. For example, in atherosclerotic lesions, the expression level of GAS6 protein can change and may promote the development of the lesion. In addition, GAS6 protein can also be used as one of the biomarkers of cardiovascular disease prognosis.
The protein has some association with other biomarkers. For example, in breast cancer, the expression level of GAS6 protein can be used to assess the prognosis and treatment effect of breast cancer together with biomarkers such as ERBB2 and EGFR.
GAS6 protein has a role in tumor treatment. For example, by regulating the expression level of GAS6 protein, tumor cells can be enhanced to radiotherapy or chemotherapy. In addition, GAS6 protein can also be used as a target for targeted therapies such as antibody-drug conjugates.
Regulating the expression level of GAS6 protein can influence the development of cardiovascular disease and the treatment effect. For example, certain drugs can inhibit the development of atherosclerotic lesions by inhibiting the expression level of the GAS6 protein. furthermore
It can be used to aid in tumor diagnosis and prognosis by measuring the expression level of GAS6 protein. For example, a low-expression GAS6 protein may predict a worse prognosis and greater tumor aggressiveness.
Expression level of GAS6 protein is related to tumor genesis, development and prognosis. For example, in patients with non-small cell lung cancer, low expression of the GAS6 protein was associated with poorer survival and higher metastasis rates. In addition, GAS6 protein can also serve as a biomarker to predict tumor response to specific treatments.
Customer Reviews (3)
Write a reviewGAS6 is a treasure in the field of scientific research due to its high catalytic efficiency, high safety and high expression level.
The short half-life and high clearance of GAS6 make its action more rapid and transient, allowing for a rapid therapeutic effect.
Green production process of GAS6 is very advanced and uses the most environmentally friendly production process and is very environmentally friendly.
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