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Recombinant Human GCK Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : GCK-1708H
Product Overview : GCK MS Standard C13 and N15-labeled recombinant protein (NP_000153) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 52.2 kDa
AA Sequence : MLDDRARMEAAKKEKVEQILAEFQL QEEDLKKVMRRMQKEMDRGLRLETH EEASVKMLPTYVRSTPEGSEVGDFL SLDLGGTNFRVMLVKVGEGEEGQWS VKTKHQMYSIPEDAMTGTAEMLFDY ISECISDFLDKHQMKHKKLPLGFTF SFPVRHEDIDKGILLNWTKGFKASG AEGNNVVGLLRDAIKRRGDFEMDVV AMVNDTVATMISCYYEDHQCEVGMI VGTGCNACYMEEMQNVELVEGDEGR MCVNTEWGAFGDSGELDEFLLEYDR LVDESSANPGQQLYEKLIGGKYMGE LVRLVLLRLVDENLLFHGEASEQLR TRGAFETRFVSQVESDTGDRKQIYN ILSTLGLRPSTTDCDIVRRACESVS TRAAHMCSAGLAGVINRMRESRSED VMRITVGVDGSVYKLHPSFKERFHA SVRRLTPSCEITFIESEEGSGRGAA LVSAVACKKACMLGQTRTRPLEQKL ISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : GCK glucokinase [ Homo sapiens (human) ]
Official Symbol : GCK
Synonyms : GCK; glucokinase (hexokinase 4); maturity onset diabetes of the young 2, MODY2; glucokinase; HK4; HK IV; hexokinase-4; hexokinase-D; hexokinase type IV; hexokinase D, pancreatic isozyme; ATP:D-hexose 6-phosphotransferase; GK; GLK; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3;
Gene ID : 2645
mRNA Refseq : NM_000162
Protein Refseq : NP_000153
MIM : 138079
UniProt ID : P35557

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there ongoing clinical trials focusing on ERBB3 inhibitors? 02/07/2021

Clinical trials exploring ERBB3 inhibitors or drugs targeting the ERBB3 pathway are ongoing to evaluate their effectiveness and safety.

Can ERBB3 inhibitors be used in combination with other cancer therapies? 10/07/2020

Yes, combining ERBB3 inhibitors with other targeted therapies or chemotherapy is being explored to enhance treatment efficacy.

How does ERBB3 contribute to resistance to certain cancer therapies? 06/29/2018

ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.

Can ERBB3 be used as a biomarker for prognosis in cancer patients? 02/08/2018

Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.

How does ERBB3 interact with other receptors in the EGFR family? 09/17/2017

ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.

Customer Reviews (3)

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Reviews
03/22/2021

    I confidently recommend the GCK protein to any researcher seeking a superior protein that not only fulfills their experimental needs but is also backed by unparalleled support from the manufacturer.

    08/06/2019

      This has greatly facilitated my experimental workflow, ensuring a readily available and dependable protein source whenever I need it.

      09/23/2018

        Its high quality, coupled with the manufacturer's exceptional technical support, make it a reliable and effective choice for addressing my scientific inquiries.

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