Active Recombinant Human GNAS protein, GST-tagged

• Cat.No.: GNAS-192H
• Product Overview: Recombinant Human GNAS fused with GST tag at N-terminal was expressed in E. coli.

Specification

• Description: Guanine nucleotide-binding proteins (G proteins) are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits, and function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (GNAS) functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 38 nmol/min/mg
• Molecular Mass: 70 kDa
• Purity: >95%
• Applications: Enzyme Assay
• Stability: 1 year at -70 centigrade date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: GNAS GNAS complex locus [ Homo sapiens ]
• Official Symbol: GNAS
• Synonyms: GNAS; GNAS complex locus; GNAS1, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; protein ALEX; GNASXL; GPSA; NESP; NESP55; SCG6; secretogranin VI; extra large alphas protein; neuroendocrine secretory protein; guanine nucleotide regulatory protein; alternative gene product encoded by XL-exon; adenylate cyclase-stimulating G alpha protein; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; AHO; GSA; GSP; POH; GNAS1; PHP1A; PHP1B; PHP1C; C20orf45; MGC33735
• Gene ID: 2778
• mRNA Refseq: NM_000516
• Protein Refseq: NP_000507
• UniProt ID: O95467