Recombinant Human GRK2 Protein, MYC/DDK-tagged

• Cat.No.: GRK2-2363H
• Product Overview: Recombinant human GRK2 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Description: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008].
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 79.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GRK2 G protein-coupled receptor kinase 2 [ Homo sapiens ]
• Official Symbol: GRK2
• Synonyms: ADRBK1; BARK1; BETA-ARK1
• Gene ID: 156
• mRNA Refseq: NM_001619.3
• Protein Refseq: NP_001610
• MIM: 109635