Recombinant Human GRN Protein, MYC/DDK-tagged
Cat.No. : | GRN-2358H |
Product Overview : | Recombinant human GRN protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293 |
- Specification
- Gene Information
- Related Products
Description : | Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. [UniProtKB/Swiss-Prot Function] |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 61.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | GRN granulin [ Homo sapiens ] |
Official Symbol : | GRN |
Synonyms : | CLN11; GEP; GP88; PCDGF; PEPI; PGRN |
Gene ID : | 2896 |
mRNA Refseq : | NM_002087 |
Protein Refseq : | NP_002078 |
MIM : | 138945 |
UniProt ID : | P28799 |
Products Types
◆ Recombinant Protein | ||
GRN-5375H | Recombinant Human GRN Protein, GST-tagged | +Inquiry |
GRN-041H | Recombinant Human GRN Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Grn-1593R | Recombinant Rat Grn Protein, His-tagged | +Inquiry |
Grn-1065M | Recombinant Mouse Grn Protein, MYC/DDK-tagged | +Inquiry |
GRN-1022H | Recombinant Human GRN Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
GRN-2412MCL | Recombinant Mouse GRN cell lysate | +Inquiry |
GRN-2791HCL | Recombinant Human GRN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
- Reviews
Q&As (6)
Ask a questionThere is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.
GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.
Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.
The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.
Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.
GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.
Customer Reviews (3)
Write a reviewThe outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.
Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.
This protein has a short half-life, high clearance rate, and high safety and efficacy.
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