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Active Recombinant Human HAO1 Protein, His-tagged

Cat.No. : HAO1-001H
Product Overview : Recombinant human HAO1 protein(1-370aa), fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
  • Specification
  • Gene Information
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Description : HAO1, also known as glycolate oxidase, is a member of the superfamily of the alpha hydroxy acid oxidases (HAO) enzymes. It catalyzes the FMN mediated oxidation of glycolate to glyoxylate and glyoxylate to oxalate with reduction of oxygen to hydrogen peroxide. It is most highly expressed in liver and pancreas and is most active on twocarbon substrates such as glycolate. Recently, it has been identified as a major contributor to hyperoxaluria, a disorder in which large deposits of calcium oxalate form kidney stones.
Source : E. coli
Species : Human
Tag : His
Form : Liquid
Bio-activity : Specific activity is > 3,000 pmol/min/μg, and defined as the amount of enzyme that oxidize glyoxylate at pH 8.0 at 25 centigrade.
Molecular Mass : 45.0 kDa
AA Sequence : MRGSHHHHHHGMASMTGGQQMGRDL YDDDDKDRWGSMLPRLICINDYEQH AKSVLPKSIYDYYRSGANDEETLAD NIAAFSRWKLYPRMLRNVAETDLST SVLGQRVSMPICVGATAMQRMAHVD GELATVRACQSLGTGMMLSSWATSS IEEVAEAGPEALRWLQLYIYKDREV TKKLVRQAEKMGYKAIFVTVDTPYL GNRLDDVRNRFKLPPQLRMKNFETS TLSFSPEENFGDDSGLAAYVAKAID PSISWEDIKWLRRLTSLPIVAKGIL RGDDAREAVKHGLNGILVSNHGARQ LDGVPATIDVLPEIVEAVEGKVEVF LDGGVRKGTDVLKALALGAKAVFVG RPIVWGLAFQGEKGVQDVLEILKEE FRLAMALSGCQNVKVIDKTLVRKNP LAVSKI
Purity : > 95% by SDS-PAGE
Notes : For research use only. This product is not intended or approved for human, diagnostics or veterin.
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 centigrade.
Avoid repeated freezing and thawing cycles.
Concentration : 1.0 mg/mL
Storage Buffer : 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.5M NaCl.
Gene Name : HAO1 hydroxyacid oxidase 1 [ Homo sapiens (human) ]
Official Symbol : HAO1
Synonyms : GOX (glycolate oxidase); GOX1; HAOX1; Hydroxyacid oxidase 1; GOX; hydroxyacid oxidase 1; (S)-2-hydroxy-acid oxidase; glycolate oxidase 1; hydroxyacid oxidase (glycolate oxidase) 1; EC 1.1.3.15
Gene ID : 54363
mRNA Refseq : NM_017545
Protein Refseq : NP_060015
MIM : 605023
UniProt ID : Q9UJM8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is HAO1 implicated in metabolic disorders? 02/14/2022

Dysregulation of HAO1 is linked to metabolic disorders and fatty liver disease.

Are there existing or potential therapeutic strategies targeting HAO1? 09/04/2021

Therapeutic approaches may include modulation of HAO1 activity or expression.

How does HAO1 contribute to fatty acid metabolism? 08/15/2020

It oxidizes specific fatty acids, contributing to their breakdown.

What are the key biological functions of HAO1? 07/14/2020

HAO1 is involved in peroxisomal fatty acid oxidation, crucial for lipid metabolism.

What are the potential consequences of HAO1 overexpression? 06/15/2020

HAO1 overexpression may lead to oxidative stress and liver dysfunction.

What role does HAO1 play in liver function? 01/01/2019

HAO1 supports liver function by participating in lipid catabolism.

How is HAO1 activity regulated in cells? 10/13/2018

Cellular regulation of HAO1 involves transcriptional and post-translational mechanisms.

Customer Reviews (3)

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Reviews
05/09/2022

    Worked well in experiments.

    11/28/2020

      Great for academic research.

      01/28/2020

        Very satisfied, will buy again.

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