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Recombinant Human HBB Protein, Myc/DDK-tagged

Cat.No. : HBB-01H
Product Overview : Recombinant protein of human hemoglobin, beta (HBB) with a C-Myc/DDK tag was expressed in HEK293T.
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Description : The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Source : HEK293T
Species : Human
Tag : Myc/DDK
Molecular Mass : 15.8 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Gene Name : HBB hemoglobin subunit beta [ Homo sapiens (human) ]
Official Symbol : HBB
Synonyms : HBB; hemoglobin subunit beta; ECYT6; CD113t-C; beta-globin; hemoglobin subunit beta; beta globin chain; hemoglobin beta subunit; hemoglobin, beta
Gene ID : 3043
mRNA Refseq : NM_000518
Protein Refseq : NP_000509
MIM : 141900
UniProt ID : P68871

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of HBB in blood and oxygen transport? 02/27/2022

HBB, part of the hemoglobin molecule, is crucial for oxygen transport in the blood.

What potential therapeutic approaches target HBB gene mutations in blood disorders? 07/29/2020

Therapies targeting HBB mutations aim to correct or compensate for the defective hemoglobin in blood disorders.

How do mutations in the HBB gene affect its protein product and lead to disease? 07/28/2020

HBB mutations can lead to abnormal hemoglobin, resulting in impaired oxygen transport and cell damage.

How does HBB contribute to the structure and function of hemoglobin? 06/27/2018

It forms part of hemoglobin's structure, binding oxygen in red blood cells.

What is the impact of altered HBB expression on oxygen delivery and overall health? 05/24/2018

Altered HBB expression affects hemoglobin's efficiency, impacting oxygen delivery and health.

How does HBB interact with other components of the hemoglobin complex? 11/03/2017

HBB interacts with other hemoglobin subunits to form a functional oxygen-carrying complex.

What role does HBB play in genetic disorders like sickle cell anemia and thalassemia? 06/05/2017

Mutations in HBB cause sickle cell anemia and thalassemia, affecting hemoglobin's function.

Customer Reviews (3)

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Reviews
03/26/2022

    Helps us reach milestones. Efficient and accurate service.

    10/01/2021

      Critical for success. Trusted for precise protein analysis.

      04/28/2021

        Supports groundbreaking discoveries. Highly recommended for research.

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