Recombinant Human HDAC1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: HDAC1-1751H
• Product Overview: HDAC1 MS Standard C13 and N15-labeled recombinant protein (NP_004955) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 54.9 kDa
• AA Sequence: MAQTQGTRRKVCYYYDGDVGNYYYG QGHPMKPHRIRMTHNLLLNYGLYRK MEIYRPHKANAEEMTKYHSDDYIKF LRSIRPDNMSEYSKQMQRFNVGEDC PVFDGLFEFCQLSTGGSVASAVKLN KQQTDIAVNWAGGLHHAKKSEASGF CYVNDIVLAILELLKYHQRVLYIDI DIHHGDGVEEAFYTTDRVMTVSFHK YGEYFPGTGDLRDIGAGKGKYYAVN YPLRDGIDDESYEAIFKPVMSKVME MFQPSAVVLQCGSDSLSGDRLGCFN LTIKGHAKCVEFVKSFNLPMLMLGG GGYTIRNVARCWTYETAVALDTEIP NELPYNDYFEYFGPDFKLHISPSNM TNQNTNEYLEKIKQRLFENLRMLPH APGVQMQAIPEDAIPEESGDEDEDD PDKRISICSSDKRIACEEEFSDSEE EGEGGRKNSSNFKKAKRVKTEDEKE KDPEEKKEVTEEEKTKEEKPEAKGV KEEVKLATRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: HDAC1 histone deacetylase 1 [ Homo sapiens (human) ]
• Official Symbol: HDAC1
• Synonyms: HDAC1; histone deacetylase 1; RPD3L1; GON 10; HD1; reduced potassium dependency, yeast homolog-like 1; RPD3; GON-10; DKFZp686H12203
• Gene ID: 3065
• mRNA Refseq: NM_004964
• Protein Refseq: NP_004955
• MIM: 601241
• UniProt ID: Q13547