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Recombinant Human HLA-DMB Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : HLA-DMB-6533H
Product Overview : HLA MS Standard C13 and N15-labeled recombinant protein (NP_002109) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 28.9 kDa
AA Sequence : MITFLPLLLGLSLGCTGAGGFVAHV ESTCLLDDAGTPKDFTYCISFNKDL LTCWDPEENKMAPCEFGVLNSLANV LSQHLNQKDTLMQRLRNGLQNCATH TQPFWGSLTNRTRPPSVQVAKTTPF NTREPVMLACYVWGFYPAEVTITWR KNGKLVMPHSSAHKTAQPNGDWTYQ TLSHLALTPSYGDTYTCVVEHIGAP EPILRDWTPGLSPMQTLKVSVSAVT LGLGLIIFSLGVISWRRAGHSSYTP LPGSNYSEGWHISTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : HLA-DMB major histocompatibility complex, class II, DM beta [ Homo sapiens (human) ]
Official Symbol : HLA-DMB
Synonyms : HLA-DMB; major histocompatibility complex, class II, DM beta; HLA class II histocompatibility antigen, DM beta chain; D6S221E; RING7; MHC class II HLA-DMB; MHC class II antigen DMB; really interesting new gene 7 protein; MHC class II antigen HLA-DM beta chain; class II histocompatibility antigen, M beta chain;
Gene ID : 3109
mRNA Refseq : NM_002118
Protein Refseq : NP_002109
MIM : 142856
UniProt ID : P28068

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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