| Description : |
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
30.8 kDa |
| AA Sequence : |
MGSGWVPWVVALLVNLTRLDSSMTQ GTDSPEDFVIQAKADCYFTNGTEKV QFVVRFIFNLEEYVRFDSDVGMFVA LTKLGQPDAEQWNSRLDLLERSRQA VDGVCRHNYRLGAPFTVGRKVQPEV TVYPERTPLLHQHNLLHCSVTGFYP GDIKIKWFLNGQEERAGVMSTGPIR NGDWTFQTVVMLEMTPELGHVYTCL VDHSSLLSPVSVEWRAQSEYSWRKM LSGIAAFLLGLIFLLVGIVIQLRAQ KGYVRTQMSGNEVSRAVLLPQSCTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
