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Recombinant Human HLA-DRB4 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : HLA-DRB4-2263H
Product Overview : HLA MS Standard C13 and N15-labeled recombinant protein (NP_068818) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 29.9 kDa
AA Sequence : MVCLKLPGGSCMAALTVTLTVLSSP LALAGDTQPRFLEQAKCECHFLNGT ERVWNLIRYIYNQEEYARYNSDLGE YQAVTELGRPDAEYWNSQKDLLERR RAEVDTYCRYNYGVVESFTVQRRVQ PKVTVYPSKTQPLQHHNLLVCSVNG FYPGSIEVRWFRNGQEEKAGVVSTG LIQNGDWTFQTLVMLETVPRSGEVY TCQVEHPSMMSPLTVQWSARSESAQ SKMLSGVGGFVLGLLFLGTGLFIYF RNQKGHSGLQPTGLLSTRTRPLEQK LISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : HLA-DRB4 major histocompatibility complex, class II, DR beta 4 [ Homo sapiens (human) ]
Official Symbol : HLA-DRB4
Synonyms : HLA-DRB4; major histocompatibility complex, class II, DR beta 4; HLA DR4B; DR4; DR-4; leukocyte antigen; MHC class2 antigen; MHC HLA DR-beta chain; MHC class II antigen DRB4; DRB1 transplantation antigen; human leucocyte antigen DRB4; MHC class II antigen HLA-DR-beta; HLA class II histocompatibility antigen, DR beta 4 chain; DRB4; HLA-DR4B;
Gene ID : 3126
mRNA Refseq : NM_021983
Protein Refseq : NP_068818
UniProt ID : P13762

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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