Recombinant Human HMGB1 protein, Mouse IgG2a Fc-tagged, low endotoxin
Cat.No. : | HMGB1-363H |
Product Overview : | Recombinant Human HMGB1 protein (Gly2-Glu215)(low endotoxin), fused to Mouse IgG2a Fc tag at N-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy. |
Source : | HEK293 |
Species : | Human |
Tag : | Mouse IgG2a Fc |
Form : | Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 51.6 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 214 |
Endotoxin : | Less than 0.1 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | HMGB1 |
Official Symbol : | HMGB1 |
Synonyms : | HMGB1; high mobility group box 1; high mobility group (nonhistone chromosomal) protein 1 , high mobility group box 1 , HMG1; high mobility group protein B1; Amphoterin; DKFZp686A04236; high mobility group protein 1; HMG3; SBP 1; Sulfoglucuronyl carbohydrate binding protein; HMG-1; high-mobility group box 1; high-mobility group (nonhistone chromosomal) protein 1; HMG1; SBP-1 |
Gene ID : | 3146 |
mRNA Refseq : | NM_002128 |
Protein Refseq : | NP_002119 |
MIM : | 163905 |
UniProt ID : | P09429 |
Products Types
◆ Recombinant Protein | ||
HMGB1-144H | Active Recombinant Human HMGB1 Protein (Met1-Asp169, C23A, C45A, C106A), N-His-SUMO tagged, Animal-free, Carrier-free | +Inquiry |
Hmgb1-1134M | Recombinant Mouse Hmgb1 Protein, MYC/DDK-tagged | +Inquiry |
HMGB1-116H | Recombinant Active Human HMGB1 Protein, His-tagged(C-ter) | +Inquiry |
HMGB1-0715H | Recombinant Human HMGB1 Protein (M1-E215), Tag Free | +Inquiry |
HMGB1-4866H | Recombinant Human HMGB1 Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
HMGB1-8447B | Active Native Bovine HMGB1 | +Inquiry |
◆ Lysates | ||
HMGB1-1677MCL | Recombinant Mouse HMGB1 cell lysate | +Inquiry |
HMGB1-2076HCL | Recombinant Human HMGB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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