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Recombinant Human HMGCL Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : HMGCL-4287H
Product Overview : HMGCL MS Standard C13 and N15-labeled recombinant protein (NP_000182) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 34.4 kDa
AA Sequence : MAAMRKALPRRLVGLASLRAVSTSS MGTLPKRVKIVEVGPRDGLQNEKNI VSTPVKIKLIDMLSEAGLSVIETTS FVSPKWVPQMGDHTEVLKGIQKFPG INYPVLTPNLKGFEAAVAAGAKEVV IFGAASELFTKKNINCSIEESFQRF DAILKAAQSANISVRGYVSCALGCP YEGKISPAKVAEVTKKFYSMGCYEI SLGDTIGVGTPGIMKDMLSAVMQEV PLAALAVHCHDTYGQALANTLMALQ MGVSVVDSSVAGLGGCPYAQGASGN LATEDLVYMLEGLGIHTGVNLQKLL EAGNFICQALNRKTSSKVAQATCKL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase [ Homo sapiens (human) ]
Official Symbol : HMGCL
Synonyms : HMGCL; 3-hydroxymethyl-3-methylglutaryl-CoA lyase; 3 hydroxymethyl 3 methylglutaryl Coenzyme A lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial; HL; hydroxymethylglutaricaciduria; HMG-CoA lyase; 3-hydroxy-3-methylglutaryl-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase; mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase;
Gene ID : 3155
mRNA Refseq : NM_000191
Protein Refseq : NP_000182
MIM : 613898
UniProt ID : P35914

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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