| Description : |
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
35.8 kDa |
| AA Sequence : |
MSTAREQPIFSTRAHVFQIDPATKR NWIPAGKHALTVSYFYDATRNVYRI ISIGGAKAIINSTVTPNMTFTKTSQ KFGQWADSRANTVYGLGFASEQHLT QVPPSPLVSANGPGEEKLFRSQSAD APGPTERERLKKMLSEGSVGEVQWE AEFFALQDSNNKLAGALREANAAAA QWRQQLEAQRAEAERLRQRVAELEA QAASEVTPTGEKEGLGQGQSLEQLE ALVQTKDQEIQTLKSQTGGPREALE AAEREETQQKVQDLETRNAELEHQL RAMERSLEEARAERERARAEVGRAA QLLDVSLFELSELREGLARLAEAAP TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
