Recombinant Human HP Protein, MYC/DDK-tagged

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Recombinant Human HP Protein, MYC/DDK-tagged

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Cat.No. : HP-1891H
Product Overview : Recombinant human HP protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description : This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 43.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : HP haptoglobin [ Homo sapiens ]
Official Symbol : HP
Synonyms : BP; HP2ALPHA2; HPA1S
Gene ID : 3240
mRNA Refseq : NM_001126102
Protein Refseq : NP_001119574
MIM : 140100
UniProt ID : P00738

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