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Active Recombinant Human HSPA5 protein, His-tagged

Cat.No. : HSPA5-1551H
Product Overview : Recombinant full length (aa 1-654) human GRP78 BiP Protein with His tag.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.
Source : E. coli
Species : Human
Tag : His
Form : 20 mM Tris-HCl, pH 7.5, 50 mM KCl, 1 mM DTT, 5 mM MgCl2.
Bio-activity : GRP78 has ATPase activity at the time of manufacture of 2.3 μM phosphate liberated/hr/μg protein in a 200 μl reaction at 37 centigrade (pH7.5) in the presence of 20 μl of 1 mM ATP using a Malachite Green assay.
Molecular Mass : 78 kDa
Storage : Stable for 2 years at -70 centigrade from date of shipment. Please aliquot to avoid repeated freezing and thawing.
Gene Name : HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [ Homo sapiens ]
Official Symbol : HSPA5
Synonyms : HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); GRP78, heat shock 70kD protein 5 (glucose regulated protein, 78kD); 78 kDa glucose-regulated protein; BiP; immunoglobulin heavy chain-binding protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; BIP; MIF2; GRP78; FLJ26106;
Gene ID : 3309
mRNA Refseq : NM_005347
Protein Refseq : NP_005338
MIM : 138120
UniProt ID : P11021

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there drugs targeting HSPA5 currently in development? 03/16/2021

Some studies explore small molecules and compounds that target HSPA5 as potential therapeutic agents, but clinical applications are still under investigation.

In what other medical conditions is HSPA5 relevant? 01/27/2021

HSPA5 is involved in various conditions, including cardiovascular diseases, diabetes, and neurodegenerative disorders.

Are there diagnostic applications of HSPA5 in cancer? 03/16/2018

Elevated levels of HSPA5 in certain cancers may serve as a diagnostic marker, providing information about the cellular stress response and potential malignancy.

Is there a relationship between HSPA5 and autoimmune disorders? 11/19/2017

HSPA5's involvement in the immune response suggests potential links to autoimmune disorders, but specific mechanisms are still being studied.

How does HSPA5 influence the immune response? 03/25/2016

HSPA5 is involved in antigen presentation, linking its role in protein folding to the modulation of immune responses.

Customer Reviews (3)

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Reviews
07/02/2022

    This level of support ensures that researchers have a seamless experience, enabling them to focus on their research goals without worrying about logistical or technical concerns.

    01/18/2020

      Its versatility in various biological applications, along with its compatibility with different techniques, strongly recommend it as a preferred reagent for researchers in the field.

      07/07/2019

        researchers highly appreciate HSPA5 protein for its excellent performance in ELISA assays and protein electron microscopy structure analysis.

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