Recombinant Human HTRA1 Mutant (R302A) Protein, Myc/DDK-tagged

• Cat.No.: HTRA1-131H
• Product Overview: Purified mutant recombinant protein of Human HtrA serine peptidase 1 (HTRA1), residues 161-369aa and mutation at(R302A) with a Myc/DDK tag was expressed in HEK293

Specification

• Description: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 22.5 kDa
• Protein length: 161-369
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: > 50 μg/mL as determined by microplate Bradford method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: HTRA1 HtrA serine peptidase 1 [ Homo sapiens (human) ]
• Official Symbol: HTRA1
• Synonyms: HTRA1; HtrA serine peptidase 1; L56; HtrA; ARMD7; ORF480; PRSS11; CARASIL; CADASIL2; serine protease HTRA1; IGFBP5-protease
  high-temperature requirement A serine peptidase 1; protease, serine, 11 (IGF binding); EC 3.4.21.-
• Gene ID: 5654
• mRNA Refseq: NM_002775
• Protein Refseq: NP_002766
• MIM: 602194
• UniProt ID: Q92743