Recombinant Human IDH1 Protein, MYC/DDK-tagged
Cat.No. : | IDH1-042H |
Product Overview : | Recombinant protein of human isocitrate dehydrogenase 1 (NADP+), soluble (IDH1 mutant R132H),with C-terminal Myc-DDK tag, expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] |
Source : | HEK293 cell |
Species : | Human |
Tag : | MYC/DDK |
Molecular Mass : | 46 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for at least 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | >50 µg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris-HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | IDH1 isocitrate dehydrogenase 1 (NADP+), soluble [ Homo sapiens ] |
Official Symbol : | IDH1 |
Synonyms : | IDH1; isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase [NADP] cytoplasmic; NADP(+)-specific ICDH; oxalosuccinate decarboxylase; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; IDH; IDP; IDCD; IDPC; PICD; |
Gene ID : | 3417 |
mRNA Refseq : | NM_005896 |
Protein Refseq : | NP_005887 |
MIM : | 147700 |
UniProt ID : | O75874 |
Products Types
◆ Recombinant Protein | ||
IDH1-2640R | Recombinant Rat IDH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IDH1-4409M | Recombinant Mouse IDH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IDH1-2012R | Recombinant Rhesus Macaque IDH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IDH1-565M | Recombinant Mouse IDH1 Protein (7-407 aa), His-tagged | +Inquiry |
IDH1-0133H | Recombinant Human IDH1 Protein (S2-L414), Tag Free | +Inquiry |
◆ Lysates | ||
IDH1-5307HCL | Recombinant Human IDH1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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