| Description : |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
154.79 kDa |
| AA Sequence : |
MKSGSGGGSPTSLWGLLFLSAALSL WPTSGEICGPGIDIRNDYQQLKRLE NCTVIEGYLHILLISKAEDYRSYRF PKLTVITEYLLLFRVAGLESLGDLF PNLTVIRGWKLFYNYALVIFEMTNL KDIGLYNLRNITRGAIRIEKNADLC YLSTVDWSLILDAVSNNYIVGNKPP KECGDLCPGTMEEKPMCEKTTINNE YNYRCWTTNRCQKMCPSTCGKRACT ENNECCHPECLGSCSAPDNDTACVA CRHYYYAGVCVPACPPNTYRFEGWR CVDRDFCANILSAESSDSEGFVIHD GECMQECPSGFIRNGSQSMYCIPCE GPCPKVCEEEKKTKTIDSVTSAQML QGCTIFKGNLLINIRRGNNIASELE NFMGLIEVVTGYVKIRHSHALVSLS FLKNLRLILGEEQLEGNYSFYVLDN QNLQQLWDWDHRNLTIKAGKMYFAF NPKLCVSEIYRMEEVTGTKGRQSKG DINTRNNGERASCESDVLHFTSTTT SKNRIIITWHRYRPPDYRDLISFTV YYKEAPFKNVTEYDGQDACGSNSWN MVDVDLPPNKDVEPGILLHGLKPWT QYAVYVKAVTLTMVENDHIRGAKSE ILYIRTNASVPSIPLDVLSASNSSS QLIVKWNPPSLPNGNLSYYIVRWQR QPQDGYLYRHNYCSKDKIPIRKYAD GTIDIEEVTENPKTEVCGGEKGPCC ACPKTEAEKQAEKEEAEYRKVFENF LHNSIFVPRPERKRRDVMQVANTTM SSRSRNTTAADTYNITDPEELETEY PFFESRVDNKERTVISNLRPFTLYR IDIHSCNHEAEKLGCSASNFVFART MPAEGADDIPGPVTWEPRPENSIFL KWPEPENPNGLILMYEIKYGSQVED QRECVSRQEYRKYGGAKLNRLNPGN YTARIQATSLSGNGSWTDPVFFYVQ AKTGYENFIHLIIALPVAVLLIVGG LVIMLYVFHRKRNNSRLGNGVLYAS VNPEYFSAADVYVPDEWEVAREKIT MSRELGQGSFGMVYEGVAKGVVKDE PETRVAIKTVNEAASMRERIEFLNE ASVMKEFNCHHVVRLLGVVSQGQPT LVIMELMTRGDLKSYLRSLRPEMEN NPVLAPPSLSKMIQMAGEIADGMAY LNANKFVHRDLAARNCMVAEDFTVK IGDFGMTRDIYETDYYRKGGKGLLP VRWMSPESLKDGVFTTYSDVWSFGV VLWEIATLAEQPYQGLSNEQVLRFV MEGGLLDKPDNCPDMLFELMRMCWQ YNPKMRPSFLEIISSIKEEMEPGFR EVSFYYSEENKLPEPEELDLEPENM ESVPLDPSASSSSLPLPDRHSGHKA ENGPGPGVLVLRASFDERQPYAHMN GGRKNERALPLPQSSTCTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
