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Active Recombinant Human IGFBP1 Protein

Cat.No. : IGFBP1-143H
Product Overview : Recombinant Human IGFBP1 was expressed in E. coli.
  • Specification
  • Gene Information
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Description : This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer, 100mM NaCl, pH 7.2
Bio-activity : ED50 was determined by its ability to inhibit IGF-I induced proliferation of MCF-7 is less than or equal to 0.5 ug/mL in the presence of 6 ng/ml of human IGF-I.
Molecular Mass : 25.4 kDa
AA Sequence : MAPWQCAPCSAEKLALCPPVSASCS EVTRSAGCGCCPMCALPLGAACGVA TARCARGLSCRALPGEQQPLHALTR GQGACVQESDASAPHAAEAGSPESP ESTEITEEELLDNFHLMAPSEEDHS ILWDAISTYDGSKALHVTNIKKWKE PCRIELYRVVESLAKAQETSGEEIS KFYLPNCNKNGFYHSRQCETSMDGE AGLCWCVYPWNGKRIPGSPEIRGDP NCQIYFNVQN
Endotoxin : Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
Purity : >95% as determined by SDS-PAGE and Coomassie blue staining
Concentration : Resuspend the protein in the desired concentration in proper buffer
Gene Name : IGFBP1 insulin-like growth factor binding protein 1 [ Homo sapiens ]
Official Symbol : IGFBP1
Synonyms : IGFBP1; insulin-like growth factor binding protein 1; IBP1; insulin-like growth factor-binding protein 1; AFBP; alpha pregnancy associated endometrial globulin; amniotic fluid binding protein; binding protein 25; binding protein 26; binding protein 28; growth hormone independent binding protein; hIGFBP 1; IGF binding protein 1; IGF BP25; placental protein 12; PP12; IBP-1; IGFBP-1; binding protein-25; binding protein-26; binding protein-28; IGF-binding protein 1; growth hormone independent-binding protein; alpha-pregnancy-associated endometrial globulin; IGF-BP25; hIGFBP-1;
Gene ID : 3484
mRNA Refseq : NM_000596
Protein Refseq : NP_000587
MIM : 146730
UniProt ID : P08833

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does IGFBP1 contribute to the development and progression of cancers, especially hormone-dependent cancers? 05/02/2022

IGFBP1 influences the progression of certain cancers, particularly those sensitive to hormonal regulation.

How do changes in IGFBP1 expression affect aging and age-related diseases? 12/17/2021

Changes in IGFBP1 expression contribute to the aging process and the development of age-related diseases.

What is the impact of IGFBP1 on fetal growth and development during pregnancy? 12/19/2020

IGFBP1 is important for fetal growth and development, regulating growth factor activity during pregnancy.

How does IGFBP1 influence muscle growth and regeneration, particularly in muscle-wasting conditions? 01/10/2020

IGFBP1 affects muscle growth and regeneration, playing a role in conditions involving muscle wasting.

What are the effects of IGFBP1 on cardiovascular health and diseases such as atherosclerosis? 08/09/2019

IGFBP1 impacts cardiovascular health, influencing factors like blood vessel growth and atherosclerosis development.

What role does IGFBP1 play in metabolic processes, particularly in glucose homeostasis and insulin sensitivity? 01/20/2018

IGFBP1 plays a crucial role in glucose metabolism and insulin sensitivity, impacting overall metabolic health.

How does IGFBP1 regulate the activity of insulin-like growth factors (IGFs) in different tissues? 01/15/2018

IGFBP1 modulates the availability and activity of IGFs, affecting growth and metabolic functions in various tissues.

Customer Reviews (3)

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Reviews
06/13/2022

    Precise antibody validation, enhances immunoprecipitation studies.

    03/12/2019

      Efficient protein purification, delivers high yield and purity.

      06/25/2018

        Dependable expertise in protein engineering, unmatched quality.

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