Recombinant Human IKZF3 Protein, MYC/DDK-tagged

• Cat.No.: IKZF3-487H
• Product Overview: Recombinant Human IKZF3, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 32.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: IKZF3 IKAROS family zinc finger 3 (Aiolos) [ Homo sapiens ]
• Official Symbol: IKZF3
• Synonyms: IKZF3; IKAROS family zinc finger 3 (Aiolos); zinc finger protein, subfamily 1A, 3 (Aiolos) , ZNFN1A3; zinc finger protein Aiolos; Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); AIO; AIOLOS; ZNFN1A3
• Gene ID: 22806
• mRNA Refseq: NM_012481
• Protein Refseq: NP_036613
• MIM: 606221
• UniProt ID: Q9UKT9