Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human IL-4

Cat.No. : IL4-504H
Product Overview : Recombinant Human IL-4 /Interleukin-4 Protein, HEK293 expressed(rhIL-4), His25-Ser153 (Accession# AAH67514)was expressed in human 293 cells (HEK293).
  • Specification
  • Gene Information
  • Related Products
Description : Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
Source : HEK293
Species : Human
Predicted N Terminal : His25
Form : Lyophilized from 0.22 μm filtered solution in 20 mM MES, 200 mM NaCl, pH6.0. Normally Mannitol or Trehalose are added as protectants. before lyophilization.
Bio-activity : The bio-activity was determined by dose-dependent stimulation of the proliferation of TF-1 cells. The ED50<0.2ng l, corresponding to a specific activity of>5X10^6 Unit/mg.
Molecular Mass : rhIL-4 contains no "tag" and has a calculated MW of 14.9 kDa. DTT-reduced protein migrates as 15 and 19 kDa protein due to glycosylation.
Endotoxin : Less than 1.0 EU per μg of the or rhIL-4 by the LAL method.
Purity : >95% purity as determined by SDS-PAGE of reduced rhIL-4.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade-8 centigrade); After reconstitution under sterile conditions for 1 month (4 centigrade-8 centigrade) or 3 months (-20 centigrade to -70 centigrade).
Gene Name : IL4 interleukin 4 [ Homo sapiens ]
Official Symbol : IL4
Synonyms : IL4; interleukin 4; interleukin-4; B cell growth factor 1; B_cell stimulatory factor 1; BCGF 1; BCGF1; BSF1; IL 4; lymphocyte stimulatory factor 1; MGC79402; binetrakin; pitrakinra; IL-4; BSF-1; BCGF-1;
Gene ID : 3565
mRNA Refseq : NM_000589
Protein Refseq : NP_000580
MIM : 147780
UniProt ID : P05112
Chromosome Location : 5q23-q31
Pathway : Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD40/CD40L signaling, organism-specific biosystem;
Function : cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (3)

Write a review
Reviews
10/17/2021

    By testing immunogenicity in animal models, detect whether an immune response is induced.

    11/09/2020

      The structure of the recombinant protein was analyzed by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy, and the results showed that the protein was stable.

      05/06/2020

        This protein has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.

        Ask a Question for All IL4 Products

        Required fields are marked with *

        My Review for All IL4 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends