Active Recombinant Human IL-4
Cat.No. : | IL4-504H |
Product Overview : | Recombinant Human IL-4 /Interleukin-4 Protein, HEK293 expressed(rhIL-4), His25-Ser153 (Accession# AAH67514)was expressed in human 293 cells (HEK293). |
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Description : | Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen. |
Source : | HEK293 |
Species : | Human |
Predicted N Terminal : | His25 |
Form : | Lyophilized from 0.22 μm filtered solution in 20 mM MES, 200 mM NaCl, pH6.0. Normally Mannitol or Trehalose are added as protectants. before lyophilization. |
Bio-activity : | The bio-activity was determined by dose-dependent stimulation of the proliferation of TF-1 cells. The ED50<0.2ng l, corresponding to a specific activity of>5X10^6 Unit/mg.0.2ng> |
Molecular Mass : | rhIL-4 contains no "tag" and has a calculated MW of 14.9 kDa. DTT-reduced protein migrates as 15 and 19 kDa protein due to glycosylation. |
Endotoxin : | Less than 1.0 EU per μg of the or rhIL-4 by the LAL method. |
Purity : | >95% purity as determined by SDS-PAGE of reduced rhIL-4. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade-8 centigrade); After reconstitution under sterile conditions for 1 month (4 centigrade-8 centigrade) or 3 months (-20 centigrade to -70 centigrade). |
Gene Name : | IL4 interleukin 4 [ Homo sapiens ] |
Official Symbol : | IL4 |
Synonyms : | IL4; interleukin 4; interleukin-4; B cell growth factor 1; B_cell stimulatory factor 1; BCGF 1; BCGF1; BSF1; IL 4; lymphocyte stimulatory factor 1; MGC79402; binetrakin; pitrakinra; IL-4; BSF-1; BCGF-1; |
Gene ID : | 3565 |
mRNA Refseq : | NM_000589 |
Protein Refseq : | NP_000580 |
MIM : | 147780 |
UniProt ID : | P05112 |
Chromosome Location : | 5q23-q31 |
Pathway : | Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD40/CD40L signaling, organism-specific biosystem; |
Function : | cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Ask a questionCustomer Reviews (3)
Write a reviewBy testing immunogenicity in animal models, detect whether an immune response is induced.
The structure of the recombinant protein was analyzed by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy, and the results showed that the protein was stable.
This protein has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.
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