| Cat. No. : |
IL11-325H |
| Description : |
Interleukin 11 (IL-11) is a protein that in humans is encoded by the IL11 gene. IL-11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. It is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. Compared to other interleukins, IL-11 relatively under-characterized. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130. Signal specificity is provided by the IL-11Ralpha subunit. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. |
| Theoretical MW (kDa) : |
19.2 |
| Form : |
Lyophilized |
| Preparation Method : |
Escherichia coli expression system |
| Purity : |
μ 98% by SDS-PAGE , μ 95% by HPLC |
| Endotoxin Level : |
< 0.2 ng/ug |
| Activity : |
The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 7TD1 cells was found to be < 0.2 ng/mL, corresponding to a specific activity of > 8 x 106 units/mg. |
| Application : |
SDS-PAGE |
| Storage : |
Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at 4°C for 1 week or store at -20°C for longer. Aliquot to avoid repeated freezing and thawing. |
| Unitprot ID : |
P20809 |
| Pathways : |
Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway |
