Active Recombinant Human IL17F protein
Cat.No. : | IL17F-129H |
Product Overview : | Recombinant Human IL17F was expressed in E. coli. |
- Specification
- Gene Information
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Description : | Interleukin 17F is a disulfide-linked homodimeric protein belonging to the IL-17 family of proinflammatory cytokines. Members belonging to this family share conserved features of cysteine-knot structures but differ in their N-terminal regions. The T-helper cell produced IL-17 family is inducible by IL15 and IL23, and IL17F induces T-cell and PBMC activation and proliferation. It also performs cartilage matrix turnover and angiogenesis prevention. Out of the IL-17 family, IL17F is the most homologous to IL17 and dimerizes in a way similar to that of nerve growth factors (NGF) and other neurotrophins. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA (with BSA as a carrier protein) |
Bio-activity : | The ED50 is 8.0-40.0ng/mL as determined by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. |
Molecular Mass : | 15.2 kDa |
Endotoxin : | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
Purity : | >95% |
Applications : | Cell Assay |
Storage : | The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade - 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
Reconstitution : | Reconstitute in sterile 4mM HCl at 25μg/mL (containing at least 0.1% human or bovine serum albumin) |
Gene Name : | IL17F interleukin 17F [ Homo sapiens ] |
Official Symbol : | IL17F |
Synonyms : | IL17F; interleukin 17F; interleukin-17F; IL 17F; ML 1; ML1; IL-24; cytokine ML-1; mutant IL-17F; interleukin-24; ML-1; CANDF6; IL-17F; |
Gene ID : | 112744 |
mRNA Refseq : | NM_052872 |
Protein Refseq : | NP_443104 |
MIM : | 606496 |
UniProt ID : | Q96PD4 |
Chromosome Location : | 6p12 |
Pathway : | IL23-mediated signaling events, organism-specific biosystem; |
Function : | cytokine activity; cytokine binding; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
Il17f-152M | Recombinant Active Mouse IL17F Protein, His-tagged(C-ter) | +Inquiry |
IL17F-4332H | Recombinant Human IL17F Protein | +Inquiry |
IL17F-145R | Recombinant Rat IL17F Protein | +Inquiry |
IL17F-4333R | Recombinant Rabbit IL17F Protein | +Inquiry |
IL17F-143H | Active Recombinant Human IL17F Protein | +Inquiry |
◆ Lysates | ||
IL17F-2045HCL | Recombinant Human IL17F cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionTumor xenografts, immune cell infiltration analysis, and therapeutic antibody testing assess IL17F's role in cancer.
Neutrophil chemotaxis assays, in vivo neutrophil tracking, and immune cell activation analysis explore IL17F's impact on neutrophil functions.
Genetic knockout models, functional assays, and gene expression analyses distinguish IL17F's unique roles.
Microbiota composition analysis, germ-free models, and immune cell profiling investigate IL17F-microbiota interactions.
Animal disease models, patient samples, and immunological assays elucidate IL17F's contribution to autoimmune diseases.
Co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and pathway-specific assays elucidate IL17F's heterodimerization and signaling.
Comparative cytokine profiling, inflammatory assays, and pathway analysis dissect IL17F's interplay with other immune mediators.
Allergen challenges, inflammatory disease models, and gene expression profiling probe IL17F's involvement in chronic conditions.
Epithelial barrier permeability assays, tissue section analysis, and cell culture models study IL17F's effects on barrier integrity.
Wound healing assays, tissue regeneration models, and histological analyses examine IL17F's effects on tissue repair.
Customer Reviews (3)
Write a reviewHigh specificity.
Good for receptor studies.
Potent in anti-bacterial assays.
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