Active Recombinant Human Il1A, HIgG1 Fc-tagged
Cat.No. : | Il1A-26682H |
Product Overview : | The extracellular domain of human IL-1a (NP_000566.3)(Ser113-Ala271) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropiccytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine isproduced by monocytes and macrophages as a proprotein, which is proteolytically processed and released inresponse to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form acytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associatedwith rheumatoid arthritis and Alzheimer"s disease. |
Source : | CHO cell |
Species : | Human |
Tag : | HIgG1 Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | cytokine activity; interleukin-1 receptor binding; protein binding |
Molecular Mass : | 44KDa (monomer) |
AA Sequence : | Ser113-Ala271 |
Endotoxin : | <0.06 eu/μg as determined by lal>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | IL1A interleukin 1, alpha [ Homo sapiens ] |
Official Symbol : | IL1A |
Synonyms : | IL1A; interleukin 1, alpha; IL1; interleukin-1 alpha; hematopoietin 1; IL 1A; IL1 ALPHA; IL1F1; preinterleukin 1 alpha; pro interleukin 1 alpha; IL-1 alpha; hematopoietin-1; pro-interleukin-1-alpha; IL-1A; IL1-ALPHA; |
Gene ID : | 3552 |
mRNA Refseq : | NM_000575 |
Protein Refseq : | NP_000566 |
MIM : | 147760 |
UniProt ID : | P01583 |
Chromosome Location : | 2q14 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem; |
Function : | copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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