Active Recombinant Human IL2 (21-153aa), Met tagged
Cat.No. : | IL2-028E |
Product Overview : | Recombinant Human IL2 (Ala21 Thr153, with an Nterminal Met) was expressed in E. coli and produced using nonanimal reagent in an animalfree laboratory. |
- Specification
- Gene Information
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Cat. No. : | IL2-028E |
Description : | Interleukin2 (IL2) is a Oglycosylated, four μhelix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, μ? T cells, B cells, dendritic cells, and eosinophils. IL2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL2 and IL2 Rμ synthesis. It contributes to T cell homeostasis by promoting the Fasinduced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes. IL2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. Thus, IL2 may be a key cytokine in the natural suppression of autoimmunity. |
Source : | E. coli |
Nterminal Sequence Analysis : | Met |
Molecular Mass : | 15 kDa |
Activity : | Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is typically 0.075 0.375 ng/mL. |
Endotoxin Leve : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >97%, by SDSPAGE under reducing conditions and visualized by silver stain. |
Formulation : | Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details. |
Reconstitution : | Reconstitute at 200 μg/mL in sterile 10 mM Sodium Acetate, pH 4.0. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Storage : | Use a manual defrost freezer and avoid repeated freezethaw cycles. 1. 12 months from date of receipt, 20 to 70 °C as supplied. 2. 3 month, 2 to 8 °C under sterile conditions after reconstitution. |
Unitprot ID : | P60568 |
Gene Name : | IL2 interleukin 2 [ Homo sapiens ] |
Official Symbol : | IL2 |
Synonyms : | IL2; interleukin 2; IL-2; TCGF; lymphokine; interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion |
Gene ID : | 3558 |
mRNA Refseq : | NM_000586 |
Protein Refseq : | NP_000577 |
MIM : | 147680 |
Chromosome Location : | 4q26-q27 |
Pathway : | Calcium signaling in the CD4+ TCR pathway; Cytokine Signaling in Immune system; Downstream signaling in naive CD8+ T cells; IL-2 Signaling Pathway; Inflammatory Response Pathway; Jak-STAT signaling pathway; T cell receptor signaling pathway |
Function : | carbohydrate binding; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; kappa-type opioid receptor binding; kinase activator activity |
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