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Active Recombinant Human il2, MIgG2a Fc-tagged, mutant

Cat.No. : IL2-168H
Product Overview : The extracellular domain of mouse IL-2 (NP_032392.1)(Ala21-Gln169) is fused to the N-terminus of the Fc portion of a mutant mouse IgG2a was expressed in CHO cell.
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  • Gene Information
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Description : The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and Blymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also sharedby interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic,which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeteddisruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential roleof this gene in the immune response to antigenic stimuli
Source : NS1 cells
Species : Mouse
Tag : MIgG2a Fc-tagged, mutant
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured using CTLL-s indicator cells. Specific Activity: 1-1.5 x106 Units/mg*.
Molecular Mass : 46KDa (monomer)
AA Sequence : Ala21-Gln169
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : Il2 interleukin 2 [ Mus musculus ]
Official Symbol : IL2
Synonyms : IL2; interleukin 2; interleukin-2; TCGF; T-cell growth factor; Il-2;
Gene ID : 16183
mRNA Refseq : NM_008366
Protein Refseq : NP_032392
Pathway : Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;
Function : carbohydrate binding; cytokine activity; cytokine activity; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is the impact of IL2 on T-cell memory formation? 04/25/2022

IL2 promotes the formation of memory T-cells.

What is the role of IL2 in the tumor microenvironment? 12/12/2021

IL2 has a pro-tumorigenic role in the tumor microenvironment.

How does IL2 interact with other cytokines in a mixed environment? 11/22/2021

IL2 synergizes with IL-12 in a mixed cytokine environment.

Does IL2 modulate the expression of checkpoint inhibitors? 06/03/2020

IL2 upregulates the expression of PD-1 checkpoint inhibitors.

What are the kinetics of IL2 internalization in T cells? 08/18/2019

IL2 is rapidly internalized by activated T-cells.

Does IL2 influence the polarization of macrophages? 07/24/2019

IL2 induces M1 macrophage polarization.

How does IL2 affect the blood-brain barrier permeability? 07/06/2018

IL2 increases blood-brain barrier permeability.

How does IL2's affinity for its receptor change under hypoxic conditions? 04/11/2018

IL2's affinity for its receptor decreases under hypoxic conditions.

What post-translational modifications affect IL2's bioactivity? 02/19/2017

IL2's bioactivity is enhanced by glycosylation.

What is the role of IL2 in the differentiation of Th17 cells? 04/20/2016

IL2 promotes the differentiation of Th17 cells.

Customer Reviews (3)

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Reviews
04/13/2022

    Potent in T-cell activation.

    07/27/2018

      Suitable for cytokine assays.

      01/07/2018

        High stability.

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