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Active Recombinant Human IL23A Protein

Cat.No. : IL23A-967H
Product Overview : Recombinant Human IL-23 consists of two subunits linked via a disulfide bond: P19, the region of Ala21- Pro189) from Accession# NP_057668, and P40, the region of Ile 23-Ser 328) from Accession# NP_002178.2, was expressed in insect cells.
  • Specification
  • Gene Information
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Description : This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
Source : Insect cells
Form : 1 x PBS
Bio-activity : The ED50 is 0.2 - 0.8 ng/ml, corresponding to a specific activity of 5 - 1.25 x 10^6 units/mg determined by mouse splenocyte IL-17A secretion, which is induced by hIL-23 in a dose dependent manner.
Molecular Mass : 53.3 kDa
Endotoxin : Less than 0.01 ng per µg protein as determined by the LAL method.
Purity : >95%, as determined by Coomassie stained SDS-PAGE.
Concentration : Protein formulated and vialed at >50 ug/mL in specified buffer
Gene Name : IL23A interleukin 23, alpha subunit p19 [ Homo sapiens ]
Official Symbol : IL23A
Synonyms : IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor; IL-23; IL-23A; MGC79388;
Gene ID : 51561
mRNA Refseq : NM_016584
Protein Refseq : NP_057668
MIM : 605580
UniProt ID : Q9NPF7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is this bioactive cyno IL-23 heterodimer (p19/p40) or just the cyno IL-23p19 subunit? 02/01/2023

Please inquiry our product manager with specific product.

Are there any FDA-approved drugs targeting IL23A? 12/22/2021

Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.

Is IL23A involved in the regulation of adaptive or innate immunity? 08/23/2018

IL23A primarily plays a role in regulating the adaptive immune response.

How is IL23A linked to the pathogenesis of ankylosing spondylitis? 01/25/2018

IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.

How does IL23A contribute to rheumatoid arthritis? 09/01/2017

In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.

How is IL23A involved in inflammatory bowel diseases like Crohn's disease? 07/03/2016

IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.

Customer Reviews (3)

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Reviews
04/18/2020

    Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.

    12/02/2016

      Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.

      02/25/2016

        Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.

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