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Recombinant Human IL2/diphtheria toxin, His-tagged therapeutic protein

Cat.No. : diphtheria toxin&IL2-P031H
Product Overview : A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
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  • Gene Information
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Description : The expression product is the active ingredient of Ontak.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 57.6 kDa
Protein length : diphtheria toxin fragments A and B (Met 1-Thr 387); IL-2(la 1-Thr 133)
AA Sequence : MGADDVVDSSKSFVMENFSSYHGTK PGYVDSIQKGIQKPKSGTQGNYDDD WKGFYSTDNKYDAAGYSVDNE NPLSGKAGGVVKVTYPGLTKVLALK VDNAETIKKELGLSLTEPLMEQVGT EEFIKRFGDGASRVVLSLPFA EGSSSVEYINNWEQAKALSVELEIN FETRGKRGQDAMYEYMAQACAGNRV RRSVGSSLSCINLDWDVIRDK TKTKIESLKEHGPIKNKMSESPNKT VSEEKAKQYLEEFHQTALEHPELSE LKTVTGTNPVFAGANYAAWAV NVAQVIDSETADNLEKTTAALSILP GIGSVMGIADGAVHHNTEEIVAQSI ALSSLMVAQAIPLVGELVDIG FAAYNFVESIINLFQVVHNSYNRPA YSPGHKTHAPTSSSTKKTQLQLEHL LLDLQMILNGINNYKNP KLTRMLTFKFYMPKKATELKHLQCL EEELKPLEEVLNLAQSKNFHLRPRD LISNINVIVLELKGSETTFMC EYADETATIVEFLNRWITFCQSIIS TLT
Endotoxin : < 1.0 EU per μg of the protein
Purity : >95%
Storage : Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles.
Gene Name : IL2 interleukin 2 [ Homo sapiens ]
Official Symbol : IL2
Synonyms : IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; involved in regulation of T-cell clonal expansion; IL-2; lymphokine;
Gene ID : 3558
mRNA Refseq : NM_000586
Protein Refseq : NP_000577
MIM : 147680
UniProt ID : P60568
Chromosome Location : 4q26-q27
Pathway : Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;
Function : carbohydrate binding; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding; kinase activator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is the impact of IL2 on T-cell memory formation? 04/25/2022

IL2 promotes the formation of memory T-cells.

What is the role of IL2 in the tumor microenvironment? 12/12/2021

IL2 has a pro-tumorigenic role in the tumor microenvironment.

How does IL2 interact with other cytokines in a mixed environment? 11/22/2021

IL2 synergizes with IL-12 in a mixed cytokine environment.

Does IL2 modulate the expression of checkpoint inhibitors? 06/03/2020

IL2 upregulates the expression of PD-1 checkpoint inhibitors.

What are the kinetics of IL2 internalization in T cells? 08/18/2019

IL2 is rapidly internalized by activated T-cells.

Does IL2 influence the polarization of macrophages? 07/24/2019

IL2 induces M1 macrophage polarization.

How does IL2 affect the blood-brain barrier permeability? 07/06/2018

IL2 increases blood-brain barrier permeability.

How does IL2's affinity for its receptor change under hypoxic conditions? 04/11/2018

IL2's affinity for its receptor decreases under hypoxic conditions.

What post-translational modifications affect IL2's bioactivity? 02/19/2017

IL2's bioactivity is enhanced by glycosylation.

What is the role of IL2 in the differentiation of Th17 cells? 04/20/2016

IL2 promotes the differentiation of Th17 cells.

Customer Reviews (3)

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Reviews
04/13/2022

    Potent in T-cell activation.

    07/27/2018

      Suitable for cytokine assays.

      01/07/2018

        High stability.

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