Active Recombinant Human IL7, His tagged
Cat.No. : | IL7-507H |
Product Overview : | Recombinant Human Interleukin-7/IL-7 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Asp26-His177) of Human IL-7 fused with a polyhistidine tag at the C-terminus. |
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Description : | Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. |
Source : | Human Cells |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 μM filtered solution of 20mM PB,150mM NaCl, pH 7.4. |
Bio-activity : | >2.0 x 10^6 U/mg |
Endotoxin : | Less than 0.1 EU/μg. |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at< -20°c, though stable at room temperature for 3>Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at< -20°c for 5> |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 3X PBS.Please aliquot the reconstituted solution |
Gene Name : | IL7 interleukin 7 [ Homo sapiens ] |
Official Symbol : | IL7 |
Synonyms : | IL7; interleukin 7; interleukin-7; IL 7; IL-7; |
Gene ID : | 3574 |
mRNA Refseq : | NM_000880 |
Protein Refseq : | NP_000871 |
MIM : | 146660 |
UniProt ID : | P13232 |
Chromosome Location : | 8q12-q13 |
Pathway : | Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Immune System, organism-specific biosystem; Interleukin-7 signaling, organism-specific biosystem; |
Function : | cytokine activity; cytokine receptor binding; growth factor activity; growth factor activity; interleukin-7 receptor binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
IL7-38H | Active Recombinant Human IL7 Protein, Animal Free | +Inquiry |
IL7-188M | Active Recombinant Mouse IL7 Protein | +Inquiry |
Il7-118M | Active Recombinant Mouse Il7 Protein | +Inquiry |
IL7-032E | Active Recombinant Human IL7 protein(Asp26-His177) | +Inquiry |
IL7-3155H | Recombinant Human IL7 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL7-5223HCL | Recombinant Human IL7 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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