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Recombinant Human IL7R protein (Glu21-Gly236), His-tagged

Cat.No. : IL7R-2260H
Product Overview : Recombinant Human IL7R protein (Glu21-Gly236)(P16871-1) was expressed in HEK293 with a polyhistidine tag at the C-terminus.
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Source : HEK293
Species : Human
Tag : C-His
Protein length : Glu21-Gly236
Form : Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Bio-activity : Human IL-7 R alpha, His Tag captured on CM5 Chip via anti-his antibody can bind Human IL-7, No Tag with an affinity constant of 4.18 nM as determined in SPR assay (Biacore T200).
Molecular Mass : The protein has a predicted MW of 25.7 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
Endotoxin : Less than 1EU per μg by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE
> 95% as determined by HPLC
Storage : -20 to -80°C for 12 months as supplied from date of receipt.
-80°C for 3-6 months after reconstitution.
2-8°C for 2-7 days after reconstitution.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Reconstitution : Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Gene Name : IL7R interleukin 7 receptor [ Homo sapiens ]
Official Symbol : IL7R
Synonyms : IL7R; interleukin 7 receptor; interleukin-7 receptor subunit alpha; CD127; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; ILRA; IL7RA; CDW127; IL-7R-alpha;
Gene ID : 3575
mRNA Refseq : NM_002185
Protein Refseq : NP_002176
MIM : 146661
UniProt ID : P16871

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the prospect of recombinant IL7R in tumor immunotherapy? 11/19/2022

IL7R is a potential drug for tumor immunotherapy, which is expected to enhance anti-tumor immune response, but further research and clinical demonstration are still needed.

Is there any research showing that recombinant IL7R can be used to treat immune system failure? 09/23/2022

Recombinant IL7R can enhance the body's immune response, but there is not enough evidence to show that it can be used to treat immune system failure.

How the role of IL7R in immunotherapy? 05/05/2022

It can enhance the immune response ability of T cells and improve the immune response of the body, so as to have a therapeutic effect on immune-related diseases.

Does IL7R have synergistic effects with immune checkpoint inhibitors? 04/20/2022

There is no clear evidence that IL7R has a synergistic effect with immune checkpoint inhibitors, but this research direction deserves further exploration.

Which diseases is IL7R associated with? 08/03/2020

IL7R has been associated with immune-related diseases such as cancer, inflammatory bowel disease, and rheumatoid arthritis.

Is there any restriction on the use of IL7R? 10/13/2019

The use of IL7R is patient specific and may be subject to some limitations, such as pregnant and lactating women and patients with certain immune-related diseases.

Customer Reviews (3)

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Reviews
02/21/2022

    The pharmacodynamic parameters of IL7R were good.

    02/01/2022

      IL7R has good compatibility and stability with various excipients.

      09/30/2021

        Strong potential to desensitize specific allergens.

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