Active Recombinant Human Interleukin 36 Receptor Antagonist
Cat.No. : | IL36RN-5660H |
Product Overview : | RecombinantHuman IL36RN protein was expressed in E. coli. Val2-Asp155. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL36RN-5660H |
Description : | IL36RN isa member of the IL-1 family of proteins. IL-1 family members include IL-1β,IL-1α, IL-1ra, IL-18 and IL-1F5-F10.All family members show a 12 β-strand,β-trefoil configuration, and all family members are believed to have arisenfrom a common ancestral gene that underwent multiple duplications. The human IL-36Ra/IL-1F5gene is in closest proximity to the gene for IL-1ra and is likely arelatively recent duplication of the IL-1ra gene. |
Source : | E. coli |
Form : | Lyophilizedfrom a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
N-terminalSequence : | Val2 |
MolecularWeight : | 17 kDa |
Activity : | Measuredby its ability to inhibit IL-36α, IL-36β or IL-36γ-induced IL-8 secretion by humanpreadipocytes. The ED50 for this effect is typically 0.25-1.25 μg/mL in thepresence of 20 ng/mL of recombinant human IL-36β. Measured by its bindingability in a functional ELISA. Immobilized recombinant human IL-36Ra at 1μg/mL (100 μL/well) can bind recombinant human IL-1 Rrp2 Fc Chimera with alinear range of 0.15-5 μg/mL. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 65 kDa,reducing conditions. |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 100 μg/mLin sterile PBS |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution. |
Gene Name : | IL36RN interleukin 36 receptorantagonist [ Homo sapiens ] |
Official Symbol : | IL36RN |
Synonyms : | IL36RN; interleukin36 receptor antagonist; FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1;IL1RP3; IL36RA; FIL1 (DELTA); interleukin-36 receptor antagonist protein; IL-1rahomolog 1; interleukin-1 HY1; IL-1 related protein 3; interleukin-1-likeprotein 1; family of interleukin 1-delta; IL1F5 (Canonical product IL-1F5a);interleukin 1 family, member 5 (delta); interleukin-1 receptor antagonisthomolog 1; IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta) |
Gene ID : | 26525 |
mRNA Refseq : | NM_012275 |
Protein Refseq : | NP_036407 |
MIM : | 605507 |
UniProt ID : | Q9UBH0 |
Chromosome Location : | 2q14 |
Function : | cytokine activity;interleukin-1 receptor antagonist activity |
Products Types
◆ Lysates | ||
IL36RN-5239HCL | Recombinant Human IL1F5 293 Cell Lysate | +Inquiry |
IL36RN-5240HCL | Recombinant Human IL1F5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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